| Pair Name | Cianidanol, Fluorouracil | ||
| Phytochemical Name | Cianidanol (PubChem CID: 9064 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cianidanol, Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->ROS-mediated apoptosis | |||
| Gene Regulation | Up-regulation | Expression | LDHA | hsa3939 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | SNU-620 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_5079 |
| Result | We suggest catechin as a candidate for the development of a novel adjuvant drug that reduces chemoresistance to 5FU by restricting LDHA. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil. Int J Mol Sci. 2021 May 20;22(10):5406. doi: 10.3390/ijms22105406. | Click |
